Clavulanic Acid(RX-10100), a major beta-lactam antibiotic produced by the organism Streptomyces claveris, is a potent bacterial beta-lactamase inhibitor used in the study of infections caused by bacteria. Clavulanic Acid has a broad spectrum of biological activity and is active against a wide variety of Gram-positive and Gram-negative bacteria.

Clavulanic acid exhibits synergistic antibacterial activity with ampicillin against microorganisms producing β-lactamase[2].
Clavulanic acid inhibits strains Ab11 and Ab51 with a minimum inhibitory concentration (MIC) ranging from 2 to 8 μg/mL[4].

In C57BL/6 mice with Pseudomonas aeruginosa pneumonia, intraperitoneal injection of clavulanic acid (13 mg/kg) reduces bacterial burden in the lungs[4].
In C57BL/6 mice infected with Ab51, intraperitoneal injection of clavulanic acid (13 mg/kg) shows a half-life (t1/2) of 6.69 hours and an area under the curve (AUC) of 4.03 mg·h/L in a lung infection model[4].
In a rat model of carrageenan-induced paw edema, intraperitoneal injection of clavulanic acid (100-300 mg/kg) exhibits anti-inflammatory effects[3].