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Clavulanic Acid

Name: Clavulanic Acid
Brand: TargetMol
SKU: T19860
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19860Cas No. 58001-44-8

Alias RX-10100, MM-14151, MM14151, MM 14151, BRL-14151, BRL14151, BRL 14151

Clavulanic Acid(RX-10100), a major beta-lactam antibiotic produced by the organism Streptomyces claveris, is a potent bacterial beta-lactamase inhibitor used in the study of infections caused by bacteria. Clavulanic Acid has a broad spectrum of biological activity and is active against a wide variety of Gram-positive and Gram-negative bacteria.

Clavulanic Acid

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Purity: 99.89%

Catalog No. T19860Alias RX-10100, MM-14151, MM14151, MM 14151, BRL-14151, BRL14151, BRL 14151Cas No. 58001-44-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	-	In Stock
25 mg	Preferential	-	In Stock
50 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Clavulanic Acid(RX-10100), a major beta-lactam antibiotic produced by the organism Streptomyces claveris, is a potent bacterial beta-lactamase inhibitor used in the study of infections caused by bacteria. Clavulanic Acid has a broad spectrum of biological activity and is active against a wide variety of Gram-positive and Gram-negative bacteria.
In vitro	Clavulanic acid exhibits synergistic antibacterial activity with ampicillin against microorganisms producing β-lactamase[2]. Clavulanic acid inhibits strains Ab11 and Ab51 with a minimum inhibitory concentration (MIC) ranging from 2 to 8 μg/mL[4].
In vivo	In C57BL/6 mice with Pseudomonas aeruginosa pneumonia, intraperitoneal injection of clavulanic acid (13 mg/kg) reduces bacterial burden in the lungs[4]. In C57BL/6 mice infected with Ab51, intraperitoneal injection of clavulanic acid (13 mg/kg) shows a half-life (t1/2) of 6.69 hours and an area under the curve (AUC) of 4.03 mg·h/L in a lung infection model[4]. In a rat model of carrageenan-induced paw edema, intraperitoneal injection of clavulanic acid (100-300 mg/kg) exhibits anti-inflammatory effects[3].
Synonyms	RX-10100, MM-14151, MM14151, MM 14151, BRL-14151, BRL14151, BRL 14151

Chemical Properties

Molecular Weight	199.16
Formula	C₈H₉NO₅
Cas No.	58001-44-8
Smiles	[H][C@@]12CC(=O)N1[C@@H](C(O)=O)\C(O2)=C\CO
Relative Density.	1.65 g/cm3

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (50.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0211 mL	25.1054 mL	50.2109 mL	251.0544 mL
5 mM	1.0042 mL	5.0211 mL	10.0422 mL	50.2109 mL
10 mM	0.5021 mL	2.5105 mL	5.0211 mL	25.1054 mL
20 mM	0.2511 mL	1.2553 mL	2.5105 mL	12.5527 mL
50 mM	0.1004 mL	0.5021 mL	1.0042 mL	5.0211 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc